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Police have launched a search after 'extremely vulnerable' teenage siblings took their parents' car and ran away.

Mukarma, 16, and her 14-year-old brother, Muhammed, are believed to have taken a family member's car – a white Toyota Prius – in the early hours of Monday.

The missing white vehicle with the registration KR10 NTF was seen travelling on the A40 Oxford Road, Gerrards Cross towards Beaconsfield.

Muhammed is described as being 5ft 9in, Asian with a slim build and shoulder-length black hair. He also often wears glasses.

His sister is said to be 5ft 3in, with a slim build and long, black, wavy hair which is often in braids. She may be wearing a Hijab and has a dimple on one side of her face.

There have been no further camera sightings of the car, and the family have not heard from either Mukarma or Muhammed.

Mukarma is said to be 5ft 3inch, with a slim build and long, black, wavy hair which is often in braids. She may be wearing a Hijab and has a dimple on one side of her face

Muhammed is described as being 5ft 9in, Asian with a slim build and shoulder-length black hair. He also often wears glasses

The siblings are believed to have taken a family member's car - a white Toyota Prius (pictured) - in the early hours of Monday

Detective Sergeant Gary Walker, who is leading the investigation, said: 'We are increasingly concerned for the welfare of Mukarma and Muhammed due to their ages, the length of time they have been missing and the belief that they may be driving a car without a licence.

'It is now a critical time in our investigation. By now the children, who are extremely vulnerable, could be anywhere in the country, so we are appealing to the public to come forward with any information or sightings.

'We are particularly keen to hear from anyone who may have offered them assistance or accommodation in recent days.

'Any piece of information, no matter how small, could be crucial to our investigation.'

Anyone who sees Mukarma or Muhammed is urged to call 999 immediately, quoting reference CAD 2117/17AUG.

Alternatively, information can be provided anonymously via Crimestoppers on 0800 555 111.