The powerful magnitude 7.1 earthquake that struck Kumamoto Prefecture on Tuesday has caused widespread disruption to regional economic activity, damaging commercial facilities and factories, and impacting logistics.

A explosion occurred at a shopping mall run by Aeon in the town of Kashima, leaving at least three people dead as rescue operations continued on Wednesday, Aeon President Akio Yoshida said.

A smokestack collapsed on Tuesday at a Nippon Paper Industries’ plant in the city of Yatsushiro, which registered upper shindo 6 on the Japanese seismic intensity scale, causing 11 people to be trapped inside. Seven of them — of whom five died — have been discovered, while four are still missing, according to the Kumamoto Prefectural Government.